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KMID : 0043320080310030342
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Archives of Pharmacal Research
2008 Volume.31 No. 3 p.342 ~ p.349
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Inhibitory Effect of Citral on NO Production by Suppression of iNOS Expression and Activation in RAW264.7 Cells
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Lee Hwa-Jeong
Jeong Heon-Sang
Kim Dae-Joong
Noh Young-Hee
Yuk Dong-Yeon
Hong Jin-Tae
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Abstract
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Citral is a major compound of lemongrass (Cymbopogon citratus L.) that has many pharmacological activities such as anti-fungal and anti-bacterial effects. In this study, we investigated the anti-inflammatory effect of citral and defined its mechanism of action in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Citral (3-12 ) significantly inhibited LPS-induced nitric oxide (NO) production in a concentration-dependent manner (). Furthermore, it was found that citral effectively inhibited the transcriptional activity and expression of iNOS, and potently suppressed the DNA binding activity and nuclear translocation of as well as phosphorylation in a concentration dependent manner. These results suggest that citral is anti-inflammatory, and its effects may be due to the inhibition of NO production through the suppression of activation.
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KEYWORD
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Citral, Nitric oxide, Anti-inflammatory
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